Wednesday, February 29, 2012

High Country Sports Arena ? Roller Skating/Hockey ? Calaveras Kids

High Country Sports Arena

209-588-0776 / highcountrysportsarena.com???????

18960 Waylon Way, Sonora, CA.

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Roller Figure Skating

Roller figure skating is the same as ice skating only done on roller skates!? This is a year round sport with competitions in the Northern California region with other Regional and National possibilities as well.? This is a one-of-a-kind sport that will differentiate you from the rest of the kids! Price:? $30 per month. Age Range: 5 years and up. Call or check website for schedule

Roller Skating?

Public roller skating sessions!? In-line or roller skate rentals are included in the price of admission. Price:? $5 ? $7. Age Range: 3 and up. Days:? Friday and Saturday??? Fri. ? 8:00 a.m. ? 10:00 p.m.? Sat. ? 5:00 p.m. ? 7:00 p.m. and 7:00 p.m. ? 9:00 p.m.? Check website for additional times.

Youth Recreational In-Line Hockey

Our in-line roller hockey is a non-contact sport for boys & girls!? Rental equipment is available for use while participating.? Our 8 and under program teaches kids how to skate and play the game. Age Range:? 5 years and up. Call or check website for prices and schedule.

Source: http://calaveraskids.com/high-country-sports-arena-roller-skatinghockey/

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Healthy Food Diet ? My Story ? One Woman's Journey With Multiple ...

My Story - One Woman's Journey With Multiple Sclerosis (MS)Above: Val Moffat, today, talks about her story and e-book. WMV format, please allow time to load or click here to download.

Valerie Moffat was diagnosed as having multiple sclerosis in May 1981. Her world was turned upside down: she faced the possibility of becoming a permanently, severely disabled person as the disease progressed. 85,000 people suffer from Multiple Sclerosis in the UK alone: Scotland, where Val lives, has the highest incidence of MS sufferers in the world.

Val assumed that the double vision, stumbling and continual tiredness she had felt since her childhood were normal parts of everyday life ? things common to everyone. It was only after her daughter?s seventh birthday party, when difficulty with breathing along with pins and needles became almost unbearable that she was checked into a hospital and diagnosed with MS.

She found it increasingly difficult to cope with the tiredness and unsteadiness of MS after her diagnosis as time passed and the condition worsened until one day in 1983.

Performing every day activities became a feat: a plight familiar to Multiple Sclerosis sufferers all over the world. Life became a struggle for her and the condition put a strain on her relationships with those around her.

After spending two years struggling with the disease, she was ready to try anything to help in her battle with the condition.

She had made simple changes to her lifestyle that relieved the terrible symptoms of Multiple Sclerosis, without the need for any medication!

At present, there is no cure for Multiple Sclerosis. Valerie?s unique discovery did not cure her MS, and her book does not contain a cure for the disease. Instead, it contains a plan to be followed that helps the body keep the symptoms of the disease under control. Val Moffat had discovered a highly simply way of controlling the disease?s symptoms without expensive medication that often have unwanted side effects.

For people with MS, the story is different. The immune system is working double time. Even the smallest exposure to toxic substances tax the immune system. And since most people don?t know where these toxins lie, or which substances are, they can?t avoid them.

Val and her husband travelled to London, Oxford, Yeovil and even Cumbria performing tests and teaching people their secret.

After these tests, the people they had tested made the necessary changes to their lifestyles and many began seeing results similar to Val?s!

Eventually, Val and her husband had tested several hundred people. They correlated the information and noticed a constant trend in their findings. From this, Valerie wrote out a plan that could be followed by all people living with MS.

"My Story: One Woman?s Journey With MS" is the life story of Valerie Moffat, MS sufferer, walking due to an extraordinary discovery after months in a wheelchair . It is a compelling story in which she shares her secret and is available for $15.99 as a 180 page+ PDF.

Filled with heart warming anecdotes, it provides a first hand insight into living with MS that will ring home with anyone familiar with the condition.

Val Moffat?s book is ideal for people who care for those with MS. By helping to alleviate many of the symptoms of MS, people with Multiple Sclerosis can regain much of their independence, providing relief for carers.

If you?ve asked this question, you?re already skeptical about Valerie?s book and her claims. Now imagine you were given the book for free, and followed her plan for 1 or 2 weeks and saw no improvement. You would most likely give up, and some of the people Val tried to help did give up after a short period time, and wrote off a chance at happiness in the process!

180 page e-book containing the inspiring life story and her amazing discoveries that fight the symptoms of MS, delivered INSTANTLY for less than the price of a quality meal! Read more?

Source: http://theequineclassifieds.com/healthy-diet-cooking/my-story-one-womans-journey-with-multiple-sclerosis-ms.html

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Tuesday, February 28, 2012

Self Improvement & Delight Resources: Fixing festering emotional ...

Introduction: Whats festering in the human body?

Would you be blown away to learn there is a little something noxious festering in the human body? Wouldnt it?s terrific to get rid of them?

Even if you believe that you are happy, you?ve got some noxious feelings undetectable in the human body, a lot of them for some time. Any self improvement pursuit or a look for happiness demands a locater to cope with this, and the work out in this posting will produce some surprising results.

I believe that these feelings are usually not, in fact, undetectable. Relatively, theyre a great deal an element of us that individuals don?t notice them, even though the accumulation continue to dines aside at us from the inside of.

We are employed injuring!

There is a physical example in this that we have: A few years ago, the spinal column pain I experienced in coaching began injuring a great deal that we really began seeking health care practitioners that could fix it. Immediately after striving numerous remedies and providers, I download firefox at some point observed the one which labored. This faded for several days. But after having a few days, my spinal column commenced injuring once more, and i also lined up looking for yet another consultation.

At first I was thinking he didnt appropriately fix the injury, and this it experienced returned. However it wasnt true. He checked out my spinal column, and told me that in fact, he had repaired that pain. This I?d been sensation was basically the discomfort that For a nice and transporting for some time earlier, caused by terrible pose and being overweight. I had put together turn out to be so utilized to it who?s didnt sign-up consciously. The main reason it sensed like fresh ache to me was due to the fact I used to be ache-no cost the week ahead of.

This is the situation for emotionally charged ache at the same time. Comparable to old physical traumas, there is a strategy for messing up the body slowly and gradually, winamp occasionally with out you recognizing.

The advantages for these sensations

These background problems undoubtedly are a tiny bit more complicated to understand then extra powerful feelings. Eckhart Tolle, as part of his strong operates Great and bad NOW in addition to a New Soil, says likely caused by a several buildings from the ego. Decide if them pertain to you:

-This shouldnt be going on to me.
-I need to get (the latest marriage, the latest employment, more cash)
-Some thing occured to me before that shouldnt have occured.

All of these hold in accordance a design of waiting waiting to live a life, watching for a little something to get you happiness, watching for a little something to become cleared in order to be no cost.

Cant yourr home is now?

Tolle procedes to make clear for you to cannot stay down the road or maybe the past. In case you watching for an upcoming event to help you happy, it wouldn?t for the time being would be the only time that you are in existence, and the only time online games you can actually be at liberty. When the foreseeable future occurs, even now opt for for a longer period the long term, the good news is. Precisely the same refers to past problems. You can not stay before, there may be but now. Ponder over it.

He also switches into depth in regards to the ego, the cause of disappointment, together with the ache-body. I wont get into them the following, but he recommends paying attention to the disappointment an element of which can be taking it and will also slowly and gradually be transmuted into what he cell phone calls Presence (an in-depth serenity and interior stillness). In essence, as you watch your disappointment, it is gone.

Take motion!

I agree with his declaration process, even so also realize that using combining declaration and letting your emotions out easily and well be more effective personally, hence the work out to some extent 2. Youll also locate this method all through other Town Monk web site.

Next: Piece Two, also discovered on the Town Monk web site. Youre able to mastery!

Source: http://icsa2010agm.com/?p=456

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Natural Chest Enhancement Pills | Grow In Knowledge

So you would like alternatives to operative breasts augmentation. Remember that efficacy of the product can also be hindered by eating an incorrect foods. It might be important to keep clear of drinking caffeinated drinks that could be a hindrance throughout enhancing your chest enhancement. If you evaluations you can find person that works well available for you and incorporate it into nutrition along with alternative alternative methods, or on an unique. Brand-new research has lead women to breast enhancement medicine. Any time you hate pop-ups, most most possibly they do excessively.

BountifulB?s is a next best though lack the structure faxing option. It will be way far too effortless develop web sites that should frustrate your visitors than get them to be stay. This is normally done by implanting a silicone on your breast enhancement pills breast. How is one to completely know who is telling the fact remains when numerous sites say various things on who is a good? It is too scary that?sthe reason there are plenty of people who are looking for fuller and firmer breast when they will undergo surgery which can lead their daily life into risk.

Some of your herbs that are regarded used in pure breast enlargement capsules are: For females with tiny that will medium bust measurements, it may use up to two months in advance of the enhancement items produce the required effect. Breast creams penetrate the epidermis, working into any fatty tissues to provide fuller and harder breasts. You certainly will surely achieve the goal that you?d like to achieve from your technology that exists today. Stay on the facts pertaining to enhancing, not all your magical things the choices can supposedly do to suit your needs.

Together with the modern technology, there are undoubtedly ways on the way to increase your busts size. But how might you make sure that it?s a reliable just one? I?m preaching about a natural breast enhancement as opposed to looking like Pamela Anderson or some other person who has acquired multiple boob tasks. What you would like is common and readily accessible, but sometimes gets lost during the hundreds of other products to choose from that might not are well. If remembering to try your breast advancement pills before afternoon doesn?t requirements, consult your pals, family, and experts for more info.

Did you ever hear about Breast development surgery? Actually, if you prefer to have bigger boobies, you can are. There are usually some side effects you do experience like, hardening of a breast, loss of sensation to your nipple, infection, uneven breast size as well as the worse is trickle and breaks. It does not just deliver the sought after results but will also direct you towards having a far healthier life. Most women can get an increase of one or two cup sizes, though some females do report a lot more growth. 6 months is the average time it does take to get desirable results.

If you ought to be safe working with natural breast enhancement pills it?s important to buy a product which may have all your needed information regarding it. Unlike typically the breast implant operations, the use of those pills is completely risk-free and can be called as 100% safe. So it is essential you need to be aware that are the realistic natural breast enlargement pills from the ones fake. It is really those breast improvement herbs that increase balanced distribution connected with herbal estrogen systems. But needless to say to see promising results it?s important to take these capsules with proper guidance from your physician. These all natural breast enlargement tablets also affect male fertility, menstrual cycle as well as effect of contraception pills.

Source: http://www.growinknowledge.com/natural-chest-enhancement-pills/

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Monday, February 27, 2012

Apple Mail and Gmail

Resolved question

Apple Mail and Gmail

by Josh K - 2/22/12 10:18 AM

Using Snow Leopard with all the latest updates. I have my Gmail account set up in Apple Mail as an IMAP account. When I delete messages in Apple Mail, the messages remain in my Inbox or Sent Items folder on the Gmail server -- if I log into Gmail via the web interface they are still in my Inbox or Sent Items.

If I delete messages using the web interface, they are also deleted from Apple Mail, so this is a one-way sync issue.

Is there a setting in Apple mail that will also delete messages from the server when I delete them in Apple Mail?

Source: http://forums.cnet.com/7723-6126_102-556681.html

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Sunday, February 26, 2012

Date already set for 2013 Knight Parade

Tampa, Fla. -- The 2012 Pin Chasers Knight Parade is only a few days old and already organizers have set a date for the 2013 event. It's scheduled for Feb. 9, 2013.

Below is a news release sent out announcing next year's date plus a recap of the this year's parade:

The 2012 Pin Chasers Knight Parade attracted nearly 120,000 spectators and more than 8,000 participants Saturday, February 18 in Ybor City.

There were 123 units in the parade along 7th Avenue, including four high school bands, grand marshal Mrs. World, April Lufrui, special guest Jerry Springer, Tampa Mayor Bob Buckhorn, Tampa Police Chief Jane Castor, and Tampa Fire Chief Tom Forward. Among the other guests also appearing in this year's parade were Telenovela star Fernando Carrillo, Miss Florida Teen America Eleana Frangedis, Miss Tampa Collins Medlin, Hillsborough County Commissioner Sandy Murman and Tampa City Council Chairman Charlie Miranda.

For the second year in a row, police reported no incidents or arrests were made at the Knight Parade.

A Tampa tradition, the Pin Chasers Knight Parade has been hosted by the Krewe of the Knights of Sant' Yago since 1974. The celebration features illuminated floats, costumed participants, marching bands, lively music, and lots of beads. The event is the Knights of Sant' Yago's largest fundraiser of the year. A portion of its proceeds benefit the Krewe of Sant' Yago Education Foundation, which to date has contributed in excess of $1,000,000 to endow scholarships at local colleges and universities.

The official name of the 2012 event was the Krewe of the Knights of Sant' Yago presents the Pin Chasers Knight Parade brought to you by Tampa Bay's MOR and estrellaTV Tampa Bay. It was also sponsored in part by the Tampa Bay Times, tbt*, 102.5 The Bone, HOT 101.5, 97X, World of Beer, Beltram Foodservice Group, Swope Rodante, Columbia Restaurant, Green Iguana - Ybor City, and the City of Tampa.

The 2013 Knight Parade is schedule for Feb. 9, 2013.

Source: http://ybor.wtsp.com/news/events/106846-date-already-set-2013-knight-parade

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Losing Michigan could commit Romney to long fight

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, speaks at a town hall meeting in Kalamazoo, Mich., Friday, Feb. 24, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, speaks at a town hall meeting in Kalamazoo, Mich., Friday, Feb. 24, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, greets supporters at a town hall meeting in Kalamazoo, Mich., Friday, Feb. 24, 2012. (AP Photo/Gerald Herbert)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, speaks at a town hall meeting in Kalamazoo, Mich., Friday, Feb. 24, 2012. (AP Photo/Gerald Herbert)

(AP) ? Losing the Michigan primary would strip the last of the varnish off the image that Mitt Romney is the inevitable GOP nominee for president and commit him to the long march he says he is prepared to wage.

While a Rick Santorum victory next week would be bad for Romney ? a public-relations nightmare for a native son of Michigan ? it would mean little to the campaign that still has more money than any other and remains better organized to compete to the end.

"There is no doubt that if he loses Michigan, perception-wise, the wheels come off the wagon," said Greg McNeely, a former Michigan Republican Party director, now unaffiliated with any of the presidential campaigns. "Can he come back? Absolutely. But it destroys the inevitability perception that has been built around the campaign."

Santorum has shot up in the polls here and even leads Romney in some as he rides a wave of momentum from winning all three Feb. 7 contests, including the Colorado caucuses that Romney won during his 2008 campaign.

Romney is responding to the Santorum threat by employing a familiar strategy: attacking his opponent's credibility. He did just that in vanquishing former House Speaker Newt Gingrich in Iowa and Florida.

On Friday, at a stop at a suburban Detroit restaurant, Romney listed positions Santorum said he had taken to support his party even though they defied his principles. Such attacks underscore the urgency of Romney's effort to blunt Santorum's challenge, as do the heavy concentration of television ads Romney is airing and the three campaign events he plans in Michigan on Saturday.

Yet, there's a lighter touch at times. Romney reminded an audience of business leaders in Detroit on Friday of his boyhood in Michigan, tossing out the name of the Detroit hospital where he was born and the school where he attended kindergarten. He's airing a television ad featuring his father, a former Michigan governor and car executive.

Even more, he offered a prescription for the long-term revival of the all-important automotive industry, calling for union concessions and less aggressive emissions standards. Those proposals might help soften any hard feelings caused by Romney's opposition to the federal bailout of the auto industry.

"I grew up with the Romney name. My parents were big Romney fans," said Ken Leonardi, owner of a restaurant in Mount Clemens, where Romney greeted several dozen supporters.

The restaurant, The Mitt, wasn't named for Romney but for the mitten shape of Michigan, although Leonardi is a Romney supporter.

"I'm planning on winning, by the way," Romney told the group.

And he may. Romney has clawed to near even with Santorum this week.

Even if Santorum beats Romney, Romney will emerge with a healthy share of delegates to add to his lead in the count, never mind fundraising and campaign organization in a race that was designed to carry into the spring.

And there is the chance for a split decision if Romney wins the popular vote but Santorum emerges with more delegates. Most of the state's 30 delegates are awarded two at a time to the winner in each of the state's 14 congressional districts.

Republican National Committee members in 2010 voted to require states holding their contests in March to award delegates based on the proportion of the vote they received, not winner take all.

Still, Romney is far better organized in key March 6 states such as Ohio and Southern bastions Georgia and Tennessee, once thought to be safe for Gingrich.

Santorum could be in for a shock if he loses Michigan, much like Gingrich did after shooting to the top of the polls in Florida after winning the South Carolina primary. He then lost Florida and struggled at fundraising afterward.

Michigan has a reputation for at times bucking the national trend, including Romney's victory over the eventual nominee, John McCain, four years ago. Similarly, then-Michigan Gov. John Engler declared in 2000 the state would be George W. Bush's firewall, only to have McCain win.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-02-25-Romney-Michigan%20Stakes/id-6a54659507a546eeb7835a59a198d46a

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Saturday, February 25, 2012

Samsung HM1800


Like last year's Samsung HM3600?($59.99, 4 stars), the $39.99 Samsung HM1800 is?an inexpensive mono?Bluetooth headset with a small, minimalist design. It improves upon the HM3600 in a number of ways, but suffers from two of the same drawbacks. Poor noise cancellation and a lack of A2DP streaming mean that this headset is only useful if you plan to keep your calls indoors.

Design, Fit, and Pairing
The HM1800 measures 1.6 by .7 by .4 inches (HWD) and weighs .28 ounces, placing it among the tiniest Bluetooth headsets we've tested. Made entirely of plastic, with a black body and dark gray front panel, it looks unobtrusive and classy. The top edge is home to a hardware power switch and LED indicator light. The back edge holds a covered microUSB charger port, while the bottom edge features two volume control buttons. The front panel contains the headset's multi-function Talk button.

The headset features an on-ear design, which means the rubber ear tip rests on your ear rather than in your ear canal.?It comes with two identical, detachable plastic ear hooks, along with three different rubber tips. One of those tips is meant to be worn in conjunction with an ear hook, while the other two allow you to use the HM1800 without a hook. Of these, I found the hook to be the most comfortable, secure option. One of the standalone rubber tips fit my ear more comfortably than the other, but neither made the headset feel completely secure. Using the hook felt safer, and because the headset is so light, it barely felt like it was even there.

The HM1800 is automatically set to pairing mode the first time you turn it on. For subsequent pairings, just hold down the Talk button for three seconds until a voice prompt says "Ready to pair." The HM1800's uses a voice prompt-based interface that provides battery and connection status updates, along with usage instructions. I found it helpful, but you can turn it off if you'd like.

Voice Quality, Noise Suppression, and Conclusions
The HM1800 is a multipoint headset, so you can pair it with two devices simultaneously. For this review I paired it with an Apple iPhone 4S?($199.99, 4 stars) as well as a Samsung Galaxy Nexus?($299.99, 4 stars). I had no trouble pairing the headset to either phone or initiating voice dialing. Battery life is good, too, at 7 hours and 36 minutes of talk time. According to Samsung, the headset should last for over twelve days on standby. Given its small size, those numbers aren't too shabby.

Voice quality is mostly good, minus one key element: noise cancellation. Voices sound rich and full through the headset, if just a touch muddy. And calls placed with it are clear, if somewhat thin. Samsung doesn't specify what type of noise suppression technology the HM1800 employs, but calls placed outdoors were extremely difficult to hear, even when it wasn't that noisy. Lots of wind came through, along with plenty of ambient noise I barely even noticed while placing the call. For that reason, I wouldn't recommend this headset if you mostly plan to use it while on the go.

Additionally, the Samsung HM1800 doesn't support A2DP, so you can't use it to listen to streaming media like apps, audiobooks, music, or podcasts, on your cell phone.

The Samsung HM1800 is small, inexpensive, and features mostly good call quality. The lack of A2DP is understandable at this price, but poor noise suppression holds this headset back. The Plantronics M50?($49.99, 3.5 stars) is another good budget option, as it adds A2DP streaming into the mix, though it too suffers from mediocre noise cancellation. The?Samsung HM6450?($99, 4 stars) is a better buy, thanks to its improved outdoor transmission quality. While it lists for $99, you can pick one up for less than $50 from numerous retailers. And if you need to be sure you can use your headset anywhere, the?pricey Jawbone Era?($129.99, 4.5 stars) is tops for noise suppression, along with the previous-generation Jawbone Icon?($99.99, 4 stars).?

More Bluetooth Headset Reviews:
??? Samsung HM1800
??? Logitech Wireless Headset
??? Plantronics M50
??? Bose Bluetooth Headset Series 2
??? Plantronics Voyager Pro HD
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/b4ITIXoHERo/0,2817,2399254,00.asp

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Oscars 2012: 7 Things That'll Be Different This Year

Regular Oscar viewers might notice a few differences when they tune in to Sunday's telecast (airing live at 8:30 p.m. ET on ABC). The annual awards show is incorporating a handful of changes this year, some of which will have a big impact on the ceremony and others that viewers likely won't even notice. Time magazine has highlighted the differences so viewers can be prepared.

Source: http://www.ivillage.com/oscars-2012-telecast-differences-ceremony/1-a-431564?dst=iv%3AiVillage%3Aoscars-2012-telecast-differences-ceremony-431564

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Friday, February 24, 2012

Indonesia moves some inmates from riot-hit prison (AP)

[unable to retrieve full-text content]AP - Indonesian authorities trying to move foreigners, women and children out of a prison hit by two days of riots returned 13 of them late Thursday to the tense, overcrowded jail on the resort island of Bali.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120223/ap_on_re_as/as_indonesia_prison_riot

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Thursday, February 23, 2012

Guidelines To Possess A Anyway-Behaved Pet dog | sspecs

If you will end up away from the residence for an lengthy time period, leaving the dog by itself when you find yourself gone, take him over a very long, energetic go walking before you give. If it is possible to tire your domestic pets out, they will likely not as stressed if it is time to go.

If your dog is not just interested in auto rides, there is still wish that. Provide your pet utilized to getting them to rides in little actions. Start by remaining together with your dog in the vehicle. Take along a few offerings along with the preferred blanket or plaything. Once youve got finished this enough occasions for him to consider cozy, shoot a quick push, maybe just appropriate down to the end of any street. Make each getaway lengthier and in no time at all your pet is certainly utilized . taking rides in the vehicle. If you wish to choosing the best canine off of the sofa or sofa you need to develop a bad reinforcement when he chooses to leap onto the piece of furniture. On one occasion he leaps onto the suspended piece of furniture, provide a intelligent, InchNo!Inches. Softly, bur solidly steer your pet switched off of any pieces of furniture. Situation dog decides to stay at your feet instead of leaping up on the sofa, prize him with a lot of praise.

To maintain your canine compliant regarding his education, make sure you continue the task well right after he has carried out the way that you possess hoped. Lots of owners will train their canines after and not perform any refreshers. Even so, animals are creatures of habit. Make sure your canine features a regular schedule.

Puppy daycare may perhaps sound like a great idea for hyperactive, sidetracked pet dogs, but every once in awhile an important drawback towards the instruction efforts. Your pet will need framework it becomes dark. Time running near and mingling with other pet dogs will make certain to tire him out, hell almost not acquire the structure was required to curtail instead of-the-leading actions. Consider a pet dog-walking web site to let your pet stretch his legs during the day preferably instead.

To ensure you succeed in coaching your puppy, you should ensure they are active in daily life. Canines usually are not sedentary wildlife. Running, enjoying and constructive physical exercise are all necessary aspects of their health and pleasure. Try signing up for an Check This Out agility class, taking a manage, or exercising Frisbee skills together with your dog. Pet dogs get bored quickly and its your career to maintain that from going on, so generally give pursuits to maintain it shifting. Interpersonal sessions with new creatures must be extremely controlled and accomplished little by little. Before choosing to implement a whole new dog, give some thought to how it will affect the Great Site household pets you currently have. Animals have diverse personas, for that reason, it is very important to select a animal using a comparable personality to your existing canine. Canine training wont be something which is not hard to perform properly, and that means you will have to do your homework. Learning how to teach your canine is nearly as essential as url discovering dog habits and exactly how they work together down in a pack. Being aware of what your pet expects originating from a bunch leader helps instruction the pet easier.

From your very start, get everybody in the household lively with the dogs training. If just one man or woman does it, then the puppy may well be more likely just to obey that one individual. Experiencing anyone undertake it, tells your dog that he must obey each member from the family members.

Related posts:

  1. Canine Training Guidelines That Can Really Work!
  2. Nevertheless at some point she is going to stop barking and
  3. Difficulties With Your Puppy? Undertake These Pointers!
  4. Canine Training Ideas That Can Actually Work!
  5. Canine Training Ideas Could Really Work!
  6. You will find tons of puppy proprietors available on the moment that wish they
  7. The Significance of Brushing
  8. When brushing pay extra awareness to the tangles in your dogs hair
  9. Set locks around the gate and any device shed or other fencing you do not
  10. What You Can Do To Simply Workout Your Dog

Source: http://www.sspecs.com/pets/guidelines-to-possess-a-anyway-behaved-pet-dog/

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All about Unified Communications

Have you heard of the term Unified Communications before? Curious as to what Unified Communications is all about? Read on to find out what it is and what it can do for your business.

Because of continued improvements in technology and changes in the way people work, we now have a multitude of options to communicate with one another. This can be both a boon and a curse, as not only do we have to learn and master a variety of devices from which to communicate?but also contend with an equal or higher number of forms with which to communicate. For example, not only do we make a phone call to talk nowadays, but we also chat, text, tweet, post, like, poke, huddle, share screens, do white board sessions, and more. We can do all of these whether on the desktop computer, laptop, netbook, tablet, desk phone, mobile phone, TV ? and soon maybe even from the kitchen refrigerator! Not surprisingly, people have started looking for ways to tame and simplify all of this complexity?and thus was born the concept of ?Unified Communications.?

Unified Communications, simply stated, encompasses the organization of different communication tools and models so that it can be used and managed in an integrated way, with the goal of improving flexibility, efficiency, and effectiveness. To illustrate the benefits of Unified Communications, here are some examples of how it can be used in several business scenarios:

  1. Have a ?single number to call? or a simpler way of reaching people. Instead of remembering and sharing a phone number, IM handle, email address, twitter account, and more, you can have just one number or address by which people can reach you?and systems will bridge that with whatever device or application your Unified Communications happen to be on or you prefer. So you can easily have calls placed to your desk phone routed to your mobile phone when you are out, and have voice mail emailed to you as a recording in case you can?t answer.
  2. Reaching people when you need them. If you are working remotely, or managing remote workers, Unified Communications systems can indicate your or your colleagues? location or ?presence??i.e., whether you or they are available at the normal location, working remotely, or out in the field.
  3. Synchronous or asynchronous way of working. If you work with people in different time zones you can opt to conference when your schedules overlap, or swap messages that can be answered at their convenience if they don?t ?and be able to track and tie all of these together.
  4. Richer collaboration. If you work on projects, Unified Communications can allow you or your team to get in touch and collaborate in a richer and more interactive way. While working on a project you can chat, switch to voice calls for better clarity, or conference via video to provide more context, as well as share screens for easier collaboration?all from a single screen or session.
  5. Application integration. Imagine if you had the ability to call people from your email application?s address book, or initiate a web conference from your instant messaging tool. With Unified Communications that is all possible.

Unified Communications may sound expensive and complex, but in reality it can actually lessen costs and make things simpler for you and your business. Learn more about Unified Communications and what else it can do to improve your business by contacting us today.

Source: http://www.techadvisory.org/2012/02/all-about-unified-communications/

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Wednesday, February 22, 2012

Treasure Coast Real Estate | BRYN MAWR Homes For Sale ...

by starfish on February 22, 2012

Find BRYN MAWR Homes For Sale and BRYN MAWR Home Values. We also have information on mortgages, insurance, movers and other Treasure Coast Real Estate Services for anyone looking to sell or buy a home in beautiful Saint Lucie COUNTY Florida.

Paul Kitchen and Starfish Team provide clients, family and close friends with professional, honest and dependable service. A resident of Treasure Coast, Paul is extremely familiar with the local neighborhoods including BRYN MAWR, school districts and the Treasure Coast Real Estate market in this beautiful Florida town.

Paul Kitchen
Broker-Owner
Starfish Real Estate
8985 SE Bridge Road Hobe Sound, Florida 33455
(772) 539-8380
(800) 793-7304 toll free
Treasure Coast Real Estate
Treasure Coast Real Estate Blog

Starfish Real Estate

Source: http://www.treasure-coast-living.com/2012/02/22/treasure-coast-real-estate-bryn-mawr-homes-for-sale-february-2012-2/

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Defiant Santorum in Obama attack

US Republican presidential hopeful Rick Santorum has renewed an attack on President Barack Obama's environmental policy, calling it "political science'.

Mr Obama unwisely limits energy production, he said, saying science supported backers of oil exploration.

Mr Santorum spoke after drawing criticism at the weekend for saying Mr Obama supported a "phony theology".

The former Pennsylvania senator has seen his support rise since winning three state contests two weeks ago.

He faces a key test in primary elections in Arizona and Michigan on 28 February.

Long-time front-runner Mitt Romney hails from Michigan, where his father served as governor, but he currently trails Mr Santorum in polling there.

Correspondents say defeat for Mr Romney in what is effectively his home state would sow panic in the Republican establishment and increase the chances of a messy, drawn-out end to the nomination process.

After Michigan several states, including key presidential battleground Ohio, will hold contests on "Super Tuesday", on 6 March.

The eventual Republican nominee will face President Barack Obama in November's general election.

'Political science'

Speaking on Monday at a campaign stop in Ohio, Mr Santorum hit out at the concept of global warming, and said that as president he would support the coal industry.

"I refer to global warming as not climate science, but political science," he said.

Two days earlier, Mr Santorum told voters that Mr Obama's agenda was based on "some phony theology, not a theology based on the Bible".

Pressed on the meaning of his comments, Mr Santorum told US Sunday talk shows that he was referring to Mr Obama's environmental policies - rather than his religious beliefs.

"This is not questioning the president's beliefs in Christianity," he told CBS News. "I'm talking about the belief that man should be in charge of the Earth, and have dominion on it, and be good stewards of it."

However, Mr Obama's campaign derided Mr Santorum's remarks as unacceptable, and he did not re-use the phrase on Monday.

"It's just time to get rid of this mindset in our politics that, if we disagree, we have to question character and faith,'' said Robert Gibbs, a former White House press secretary.

Mr Obama recently refused permission for a Canadian firm to build a major pipeline, called Keystone XL, from the oil sands of Alberta, Canada, to the Gulf of Mexico.

Environmental concerns shaped his eventual decision, drawing criticism from those backing the pipeline and calling for greater US energy independence.

Mr Santorum said on Monday that he would approve the pipeline if elected.

General election worries?

Mr Santorum has seen an increased focus on his campaign since winning contests in Missouri, Colorado and Minnesota on 7 February.

Despite more press scrutiny, though, he has maintained impressive poll numbers. The latest national Gallup tracking poll shows Mr Santorum leading Mr Romney, a former Massachusetts governor, by 10 points.

He is also polling strongly in Michigan, although a new poll shows Mr Romney improving his position in the state - rising to 33% support behind Mr Santorum's 37%.

As the primary nears, the Romney campaign has increased the pace of TV advertising in Michigan, including attacks on Mr Santorum - whom they paint as an unreliable guardian of the US economy and a veteran of a broken Washington system.

Mr Romney is also planning to make a major economic speech on 24 February at Ford Field, home to the Detroit Lions NFL team.

The prospect of a Santorum win in Michigan and an extended nomination process - and even a possible Rick Santorum candidacy - has left some Republicans concerned about their chances in November's general election.

An unnamed Republican senator told ABC News on Sunday the party would be "killed" if Mr Romney's nomination was not finalised until August.

"He'd be too damaged, if he can't even win in Michigan, where his family is from, where he grew up."

If Mr Santorum or former House Speaker Newt Gingrich emerged as the nominee, they would lose 35 states in a general election match-up with Mr Obama, the senator predicted.

Mr Gingrich, who has struggled since winning January's South Carolina primary, also told Fox News that any candidate who lost his home state contest would be "very badly weakened".

Mr Gingrich faces his home state primary, in Georgia, on Super Tuesday.

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/world-us-canada-17104543

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Afghanistan: Demonstrators Torch Foreign Compound In Kabul After Quran-Burning At U.S. Base

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Easy Bathroom Remodeling | Home Improvement On Post

Sometimes, many people assume that bathroom remodeling is a very difficult and expensive. To that end, home improvement will try to break that notion, that bathroom remodeling can be done easily. But this is a small project, so you will not cost very much. But if you do this, then you have to make changes in your bathroom.

When you come into the bathroom, you may feel uncomfortable, do not care about your status (single or married). Maybe you have a bad experience when brushing your teeth, or you have to keep the items on the table. To get rid of that experience, then you can add a bathroom sink and cabinet. To get the best cabinet, please read the guide to buying a bathroom cabinet. By doing a double sink replacement, then you can make a bathroom more enjoyable.

We still have an easy way to bathroom remodeling, so you can improve the area. You can install a spa in your bathroom. This is a very good idea and can make you relax when I go home. You can choose colors from a spa to suit your bathroom design.

Easy Steps to Bathroom Remodeling Easy Bathroom Remodeling

Then, you can make changes on the bathroom floor. By making this change, then you can turn your bathroom into a more beautiful. You can choose a floor with a dark color, this will make the room a more comfortable atmosphere. Or vice versa. It all depends on your own. If you want a bathroom floor is not slippery, so you can use porcelain floor tiles, or you can read the guide to choosing the best bathroom flooring.

Bathroom paint can change everything. Color selection is very influential in the bathroom lighting, and effects that will arise. For example, you choose the color white, so your bathroom will look more bright and spacious, and vice versa. Bathroom remodeling efforts should not make you difficult to implement.


Original Post In >> HomeImprovementBiz.com >> Easy Bathroom Remodeling

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  • Bathroom Accessories and PrototypesChoose Bathroom Accessories and Prototypes
    Bathroom Accessories ? If you think about life and the beautiful tiles with the prototypes, they often think that their machines. Often, several prototypes of a selection of fine bathroom accessories, such as linoleum and showers all. Bathroom Accessories and Prototypes If you are looking at the end of the old style, or simply add

Source: http://homeimprovementbiz.com/home-improvement/easy-bathroom-remodeling.html

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Monday, February 20, 2012

Greek premier rushes to Brussels to secure bailout (AP)

[unable to retrieve full-text content]

A protester waves  a Greek flag in front of  the parliament in central Athens as few hundred protesters gather to protest against the government's austerity measures during an anti-government rally on Sunday, Feb. 19, 2012.(AP Photo/Petros Giannakouris)AP - Greece's prime minister rushed to Brussels on Sunday, a day before eurozone finance ministers have to decide whether his country will get a euro130-billion ($170-billion) bailout and avoid a potentially devastating default.


Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/ap/20120219/ap_on_bi_ge/eu_greece_financial_crisis

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Finding the Best Low Cost Web Hosting Service for your Business Site

Published by carol | February 19, 2012 | | 18

As internet is becoming as major business platform, most of the small and large business entrepreneurs are looking for an option to obtain a position in this online. Although running a website was an expensive task in the past days, with the advancing technology, you will be able to make an online visibility of your business without much hassle. There are many service providers in the market, who are providing low cost web hosting services for the customers. These hosting companies are helping many individuals as well as companies to upload their websites on the internet. However, when it comes to obtaining the best yet cheap service, it is very important to do proper research and look for the right company.

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There are different ways, which you can use for obtaining cheap services. When you are looking for cheap hosting online, you will also come across many service providers, who are offering free services.

However, most of them are not able to provide satisfying results. Moreover, most of them also have different types of hidden costs and charges. It is also very important to look for a reliable company when you are selecting one. As there are chances of experiencing different types of problems on your website, you should select a service provider, who can provide you instant solutions. You should also make sure the company is providing customer as well as technical support within a short time.

?

When you are looking for a hosting company, looking on the internet can help you to find the best. As you will be able to know more about the different types of services provided by the hosting companies on their websites, you can select the right one that suits your needs and budget.

Most of the low cost web hosting companies will provide different types of packages and deals on the website for the customers. Therefore, you can compare them and select the right one for your website. Reading the reviews and feedbacks of the customers can give you good knowledge on the quality of the services provided by the company.

Nelson Carlin writes informative and unique articles about Linux Dedicated Server and Dedicated ServersOne thing that separates Nelson Carlin from others is the passion he puts into it, knowing full well and respecting the time viewers spend on reading his work.

Source: http://www.1directory.net/internet-and-businesses-online/web-hosting/finding-the-best-low-cost-web-hosting-service-for-your-business-site-6293.html

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Sunday, February 19, 2012

Faq's About Wills, Living Wills and Forces of Attorney | No Questions ...

Aife Insurance

Exactly What Does A Is Going To Do?

The easiest way to make sure that your funds, property and private effects is going to be distributed after your dying based on your wishes would be to make a will. A will is really a legal document assigning the transfer of your dwelling and assets once you die. Usually, wills could be compiled by anyone older than 18 who's psychologically capable, generally mentioned as "being of seem body and mind.Inch

WHO Requires A WILL?

Although wills are really simple to create, about 50 % of People in america die with out them (or Intestate). With no will to point your wishes, a legal court stages in and distributes your home based on the laws and regulations of the condition. Wills are not only for that wealthy the quantity of property you've does not matter. A will guarantees that what assets you have will be presented to family people or any other receivers you designate. For those who have no apparent beneficiaries and die with no will, it's even possible the condition may claim your estate.

Getting a will is particularly important for those who have youthful children since it provides you with the chance to designate a protector on their behalf in case of your dying. With no will, a legal court will appoint a protector for your kids who might be someone you don't know.

Do You Know The Aspects Of A WILL?

That which you generally desire to make a will:

1) Your title and home

2) Names and addresses of spouse, children along with other receivers, for example non profit organizations or buddies

3) Alternate receivers, in case a beneficiary dies before you decide to do

4) Title and address of the Executor/ Executrix to handle your estate

5) Title and address of the alternative Executor/Executrix, in case the first option is not able or reluctant to do something

6) Title and address of the protector for the minor children

7) Title and address of the alternative protector, in case the first option is not able or reluctant to do something

8) Age you want your minor children to possess charge of their inheritance

9) Any funeral demands you might have (cremation, where you need to be hidden, etc.)

10) Your signature

11) Two Witnesses' signatures and

12) Notarization.

Two of the most basic products incorporated inside your will are naming a protector for minor children and naming an Executor/ Executrix.

Exactly What Is A Protector?

Generally, a making it through parent assumes the role of sole protector. However, you need to title a protector for minor children inside your will just in case neither you nor your partner is actually able and prepared to act. The protector you select ought to be over 18 and prepared to assume the duty. Speak with the individual in advance about what you're asking. You are able to title a few as co-parents, but that won't be advisable. It certainly is possible the parents might want to go their separate ways at some future date, and, if that's the case, a custody of the children fight could ensue. If you don't title a protector to look after your kids, a judge will appoint one, and it might not be somebody you'd have selected.

Exactly What Is A EXECUTOR/EXECUTRIX AND Exactly What Do They Are Doing?

An Executor/Executrix is the one who runs the distribution of the assets in compliance together with your will. Many people choose their spouse, a grownup child, a family member, or perhaps a friend to satisfy this duty.

If no Executor/Executrix is known as inside a will, a Probate Judge will appoint one. Probate refers back to the legal technique of the orderly distribution of property inside a person's estate. The Executor/Executrix files the desire in probate court, in which a Judge decides when the will applies. If it's discovered to be valid, assets are distributed based on the will. When the will is discovered to be invalid, assets are distributed in compliance with condition laws and regulations.

Duties usually carried out by an Executor/Executrix include:

--Having to pay valid creditors

--Having to pay taxes

--Notifying Social Security along with other agencies and firms of the dying

--Eliminating charge cards, magazine monthly subscriptions, etc. and

--Disbursing assets based on the will.

How About Upgrading MY WILL?

You'll most likely have to improve your will several occasions throughout the path of your existence. For instance, a general change in marital status, the birth of the child or perhaps a move to a different condition really should prompt overview of your will. You are able to improve your will by improving it using a Codicil or by creating a replacement. Generally, people decide to problem a brand new will that supersedes that old document. Make sure to destroy that old will once you sign a replacement.

How About ESTATE TAXES?

The home incorporated inside your will might be susceptible to taxation. In planning your will, consider the next:

---Federal estate taxes will normally be due when the internet taxed estate may be worth a lot more than ,000,000. This amount is scheduled to progressively increase from ,000,000 in 2002/2003 to ,500,000 last year to ensure that it is going to shield ,500,000 in gift or estate transfers from tax per citizen. Estates more than the exempt amount could be taxed for a price from 37% to 50% (the very best percentage is scheduled to progressively decrease to 45% last year). Also, observe that these estate tax changes are scheduled to become repealed this year. Otherwise extended, the tax law will revert towards the estate and gift tax provisions in affect in 2001. Consult a tax or financial professional to find out an agenda that's suitable for your family.

---Condition dying or inheritance taxes

---Federal taxes

---Condition taxes

You might have the ability to minimize your estate tax by creating a trust or giving gifts throughout your daily life. You may also cover the price of estate taxes by buying a life insurance policy meant to pay taxes. Speak to your life insurance agent to discover much more about the salt water evaporates.

WHERE Must I KEEP MY WILL?

When your will is written, store it inside a rut that's available to others after your dying. I would recommend that you simply ensure that it stays inside a fire proof box that you could purchase at any office supply store. I don't claim that you retain your will inside a safe deposit box because many states will seal your safe deposit box upon your dying. Make certain a detailed friend or relative knows how to locate your will.

Exactly What Is A LIVING WILL?

A full time income will isn't a a part of your will. It's a separate document that allows your loved ones people know which kind of care you need to do or don't wish to receive in the event you become crictally ill or permanently unconscious. It might be effective only if you can't express your wishes yourself. Discuss your wishes as reflected inside your living will with family people, and make certain all of your doctors possess a signed copy.

Exactly What Is A Energy OF ATTORNEY FOR Healthcare (Healthcare PROXY)?

A energy of attorney for healthcare (healthcare proxy) isn't a a part of your will. It's a separate document that authorizes someone you title to do something in compliance together with your medical intentions. It might be effective only if you can't express your wishes yourself. You need to make certain that your doctors possess a signed copy.

Exactly What Is A FINANCIAL DURABLE Energy OF ATTORNEY?

An economic durable energy of attorney isn't a a part of your will. It's a separate document that authorizes someone you title to do something inwith your financial intentions. It might be effective only whenexpress your wishes yourself. You need to make certain that your financial professionals (companies, an accounting firm, financial organizers) and banks possess a signed copy.

Plan In Advance

The finish of the existence is one thing you most likely don't wish to obsess with, but considering what's going to occur to your family members as well as your assets and private possessions is essential. Ensuring you have done all you are able to create their lives simpler provides you with satisfaction. And when your will is drafted, you will not need to consider it again unless of course something significant inside your existence changes.

Source: http://noquestionsaskedlifeinsurance.bc9y.com/frequently-asked-questions-about-wills-living-wills-and-powers-of-attorney/

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Tribes Advance In Legal Battle Over Casino Licenses ? CBS Boston

BOSTON (AP) ? A federal judge has thrown out a lawsuit that alleged the state?s casino law is unconstitutional because it gives an advantage to federally recognized Indian tribes.

Lawyers for KG Urban Enterprises, which wants to build a casino in southeastern Massachusetts, had argued the law prevents the company from competing ?on an equal footing.?

The law authorizes up to three casinos in Massachusetts and gives tribes like the Mashpee Wampanoags until July 31 to negotiate a gaming compact with the state in the southeast. Only if they fail would other applicants be allowed to seek a license for the area.

There are no restrictions in other parts of the state.

In his ruling Friday, US District Judge Nathaniel Gorton sided with lawyers for the state and dismissed the complaint, saying the law is constitutional

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(? Copyright 2011 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)

Source: http://boston.cbslocal.com/2012/02/18/tribes-advance-in-legal-battle-over-casino-licenses/

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Saturday, February 18, 2012

Nigerian "underwear" bomber gets life in prison in U.S. (Reuters)

[unable to retrieve full-text content]Reuters - A federal judge on Thursday sentenced a Nigerian man to life in prison for trying to blow up a U.S. airliner bound for Detroit on Christmas Day in 2009 with a bomb hidden in his underwear.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20120217/wl_nm/us_usa_security_bomber

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GM records its highest profit ever: $7.6 billion (AP)

DETROIT ? General Motors earned its largest profit ever in 2011, two years after it nearly collapsed into financial ruin.

Strong sales in the U.S. and China helped the 103-year-old carmaker turn a profit of $7.6 billion, beating its old record of $6.7 billion in 1997 during the pickup truck and SUV boom.

GM is a vastly different company than it was back then. It's smaller, has less debt and its contract with the United Auto Workers is less costly. But it took a government bailout and a trip through bankruptcy protection in 2009 to cut its bloated costs. The company made record money last year even though U.S. auto sales were near historic lows at 12.8 million cars and trucks.

But problems surfaced in its 2011 results. GM lost $747 million before taxes in Europe, and its South American operations lost $122 million. Sales growth slowed in the U.S. in the fourth quarter, even as more Americans bought cars and trucks.

Also, GM's fourth-quarter profit fell 8 percent and results missed Wall Street expectations.

GM's stock price fell 8 cents, or 0.3 percent, to $24.85 in premarket trading.

The U.S. government still owns 26.5 percent of the company and is waiting for the share price to rise before selling in an effort to recoup the bailout money.

Last year, GM made the bulk of its income in North America, where its pretax profit totaled $7.2 billion. International Operations, which includes Asia, made $1.9 billion before taxes, but that was down.

During the year, GM's global sales rose 7.6 percent to 9.03 million vehicles to help it reclaim the title of world's largest automaker from Toyota Motor Corp.

"We will build on these results as we bring more new cars, crossovers and trucks to market," CEO Daniel Akerson said.

This year, GM expects to increase its revenue as global auto sales grow and it charges more for models. However, it will make less money per vehicle as the mix of sales continues to shift to cars from trucks, which have bigger sticker prices. It also expects to invest $8 billion on new products and technology, and says pension expenses will rise. The company wants to keep expenses down by freezing its underfunded U.S. pension plan for salaried workers.

Chief Financial Officer Dan Ammann said the company's restructuring in Europe cut pretax losses by more than $1 billion from 2010, but it didn't go far enough.

He hinted that GM will have to cut factories and jobs in the region, saying the whole auto industry has too many factories there.

"We clearly have work to do in Europe, we have work to do with the South American business," he said.

The 2011 profit of $4.58 per share was 62 percent higher than a year earlier. Full-year revenue rose 11 percent to $150 billion.

GM said 47,500 blue-collar workers in the U.S. will get $7,000 profit-sharing checks in March. The checks are based on North American performance and are a record for the company.

The company has placed Vice Chairman Steve Girsky in charge of the European management board and is adding executives in preparation for restructuring. Factory closures and layoffs are likely but could provoke a fight with powerful labor unions.

Girsky has said GM intends to fix the European unit, made up of the Opel and Vauxhall brands, and keep it in the company. GM came close to selling the unit in 2009.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120216/ap_on_bi_ge/us_earns_general_motors

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Friday, February 17, 2012

Thursday, February 16, 2012

Missing Mickey Mouse spurs school lockdown in Ohio (AP)

[unable to retrieve full-text content]AP - A northeast Ohio elementary school says a missing Mickey Mouse spurred a brief lockdown while parents were visiting the school for Valentine's Day parties.

Source: http://us.rd.yahoo.com/dailynews/rss/education/*http%3A//news.yahoo.com/s/ap/20120216/ap_on_re_us/us_school_lockdown_mickey_mouse

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Possible link to hyper-excitability factors in epilepsy, autism and more

ScienceDaily (Feb. 14, 2012) ? A UT Dallas undergraduate's research is revealing new information about a key protein's role in the development of epilepsy, autism and other neurological disorders. This work could one day lead to new treatments for the conditions.

Senior neuroscience student Francisco Garcia has worked closely with Dr. Marco Atzori, associate professor in the School of Behavioral and Brain Sciences (BBS), on several papers that outline their findings about interleukin 6 (IL-6) and hyper-excitability. An article on the project is slated for publication in Biological Psychiatry later this year.

Scientists know that stress elevates the levels of pro-inflammatory cytokines (signaling molecules used in intercellular communication) and promotes hyper-excitable conditions within the central nervous system. This hyper-excitability is thought to be a factor in epilepsy, autism and anxiety disorders.

Garcia and Atzori hypothesized that the protein IL-6 acutely and directly induces hyper-excitability by altering the balance between excitation and inhibition within synaptic communication. In other words, IL-6 is not just present when hyper-excitability occurs in the nervous system. It may actually cause it in some circumstances, Garcia said.

The UT Dallas research team administered IL-6 to rat brain tissue and monitored its synaptic excitability. The brain tissue exhibited higher than normal excitability in their synapses, a symptom that may lead to misfiring of signals in epilepsy and other conditions.

The researchers then injected sgp130 -a novel drug that acts as an IL-6 blocker- into the laboratory animals' brains. The substance limited excitability and appeared to prevent the conditions that lead to related neurological and psychiatric disorders, Garcia said.

"This finding has the potential to lead to eventual new treatments for epilepsy, anxiety disorders or autism," Garcia said.

The next stage of his research will involve looking at how IL-6 might affect development of other types of neurological problems. Human trials could follow sometime in the future.

Garcia is a native of Mexico, and he plans to pursue his master's degree in neuroscience at UT Dallas after finishing his undergraduate studies. He credits the BBS faculty with allowing him to participate in laboratory experiments and expand his research skills.

"The UT Dallas faculty members have been great about giving me the opportunity to learn the techniques of a lab researcher," he said. "It's been a great experience to work as an undergraduate with such highly respected scientists as Dr. Atzori and Dr. Michael Kilgard."

Atzori also praised Garcia's efforts.

"Francisco has been an intelligent, hard-working and experimentally gifted student who contributed way more than the average undergraduate to the projects of the laboratory," Atzori said. "I am proud that a fine piece of research with great potential for research and clinical applications has been carried out thanks to his enthusiasm and dedication. Francisco's work in my laboratory is an example of the achievements possible when an institution like UT Dallas invests in and nurtures its research environment."

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  1. Francisco Garcia-Oscos, Humberto Salgado, Shawn Hall, Feba Thomas, George E. Farmer, Jorge Bermeo, Luis Charles Galindo, Ruben D. Ramirez, Santosh D'Mello, Stefan Rose-John, Marco Atzori. The Stress-Induced Cytokine Interleukin-6 Decreases the Inhibition/Excitation Ratio in the Rat Temporal Cortex via Trans-Signaling. Biological Psychiatry, 2011; DOI: 10.1016/j.biopsych.2011.11.018

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Source: http://www.sciencedaily.com/releases/2012/02/120214134938.htm

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